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FIND NEW TARGET AND
DRUG INDICATIONS

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Drug
Repositioning

Find novel drug target indications by simultaneously assessing gene variants & expression, role in disease mechanism and availability of in-vivo/vitro models.
Faster.



DRUG REPOSITIONING EXAMPLE

HOW IT'S DONE
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One-Click Assessment of All Potential Indications

Leverage our millions of gene annotations to evaluate all possible alternative indications for your target of interest. Find the most likely indications by simultaneously evaluating each indication for known gene variants, differential expression, cellular dysfunctions, pathways, symptoms, therapeutic agents and availability of in-vivo/vitro models

Drug Repositioning, Accelerated.



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Summary of Drug Repositioning Capabilities

GENETIC INVOLVEMENT

Differential expression - for the drug repositioning indication (disease tissue vs healthy) where the selected target is either down-regulated (if agonist mechanism of action was selected) or up-regulated (if antagonist mechanism of action was selected)

Clinical gene variant findings - where the selected target is mentioned as a causative variant for the drug repositioning indication. GWAS references are explicitly excluded.

TARGET ROLE IN DISEASE MECHANISM

Symptoms - associated with the selected target as well as the drug repositioning indication

Cellular dysfunctions - associated with the selected target as well as the drug repositioning disease indication

Pathways - involving both the selected target and the drug repositioning disease indication

Co-occurrence publications - which mention both the selected target and the drug repositioning disease indication

Detailed overview of direct and especially indirect gene-disease interactions - such as comorbidity, gene-gene/protein-protein/small molecule interactions and physiological processes or pathways involved. The indirect relations provide key background information to assess drug repositioning viability even when no direct literature exists

AVAILABLE IN VIVO/VITRO EXPERIMENTAL MODELS

In-vitro experimental models - in which the selected target is analysed in context of the drug repositioning disease indication

Availability of in vivo model organisms - for the drug repositioningdisease indication