A recent publication in Nature has shown the TAK1 protein (also known as MAP3K7) is vital in regulating the survival and proliferation of satellite stem cells which are responsible for repairing damaged skeletal muscle tissue. Only recently another protein, TRAF6, was identified having the same effect. Skeletal muscle repair affects millions of people with muscular dystrophy, cancer cachexia and other muscle-wasting conditions, including aging.
When MAP3K7 is reduced, satellite stem cells become less active and eventually die in a process called necroptosis, halting the process of muscle repair. The NFkb signaling process and JUN kinase activitiy were identified as key pathways involved in the process.
Using the Euretos Analytics application for Multi-Omics Analysis, all the main components of the mechanism described above were predicted with very high levels of likelihood. Although MAP3K7 had not before been directly linked in literature, it is very strongly indirectly related to Muscular Dystrophy (91%), satellite cells (97%), necroptic process (94%) and JUN kinase activity (99%). This groundbreaking ability provides researchers with a unique capability to evaluate hypotheses before spending effort and resources on lab or clinical investigations.
In order to assess the scientific evidence of these predicted interactions, the researcher is provided with a very detailed analysis of the underlying biological mechanisms. In this case, hundreds of interactions were found such as gene-gene, RNA expression, protein-protein, chemical and pathway interactions. These indirect interactions would be very difficult and time consuming to find, one by one, using traditional search approaches and they provide excellent angles for further research into this promising mechanism
The Euretos Knowledge Platform connects over 7 million known phenotypic, genetic, proteomic, metabolic and chemical concepts in a single ultra-performance environment. All content is directly derived from scientific literature and databases with full references to sources. Apart from scope and performance, the Euretos Knowledge Platform is unique in providing the similarity, specificity and interaction strength of all its connections, even predicting their likelihood if not existing. This truly enables better answers to research questions. Faster.