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Euretos AI Platform discovers key disease mechanisms for recently identified gastric cancer target.



Tuesday 21 August 2018

In a recent study published in Nature Scientific Reports, researchers identified AEBP1 as a novel potential target for gastric cancer. The study found that both the mRNA and protein levels of AEBP1 were significantly increased in gastric cancer tissues and correlated with poor overall survival in patients. Silencing AEBP1 markedly suppressed the proliferation, migration, invasion, metastasis and epithelial-mesenchymal transition of gastric cancer cells.

As the researchers state, the specific mechanism of AEBP1’s involvement in gastric cancer is at present largely unknown. Using the Euretos AI Platform, however, an exhaustive analysis of known direct and indirect associations between AEBP1 and gastric cancers shows several key aspects of the disease mechanism.

Using the semantic search engine, it becomes clear that there is limited literature on AEBP1’s involvement in neoplastic processes. It is mentioned in the context of a number of cancers and key processes such as metastasis, tumor progression and carcinogenesis:

Figure 1: Search result of AEBP1 and associated neoplastic disorders and processes (source: Euretos AI Platform)

When searching for Gastric cancer, no direct references are available. The Euretos AI platform, however, offers the option to analyse the involvement of any gene in any disease regardless of direct involvement by leveraging over 200 semantically integrated data sources and look for associations based on the interacting genes with AEBP1 to assess it’s indirect effects. This workflow shows that EABP1 interacts with 5 genes that are also associated with gastric cancer:

 Figure 2: Gene-Disease Analysis workflow showing genes that are associated with AEBP1 as well as gastric cancer (source: Euretos AI Platform)

Using this ‘gene interactome’ as the basis for further analysis, various aspects are evaluated including involvement in gastric cancer related differential expression, gene mutations, animal models, metabolic interactions and key physiological processes such as pathways, phenotypes, molecular dysfunctions and cell & tissue functions.

In terms of dysregulation, other experiments confirm the differential expression of AEBP1 in gastric cancer:

Figure 3: Dysregulation analysis of AEBP1 and its gastric cancer specific interactome (source: Euretos AI Platform)

The Gene-Disease Analysis workflow also provides an analysis of key physiological processes such as pathways, phenotypes, molecular dysfunctions and cell & tissue functions. The top 5 physiological processes are highlighted in which AEBP1 plays a role and which are also most associated with gastric cancer.

The Pathway analysis shows that AEBP1 exerts its influence through various indirect interactions within the WNT signalling pathway and the innate immune system, both well known aspects of tumor development in gastric cancer.

 Figure 4: Pathway analysis of AEBP1 and it’s gene interactome revealing key associations with gastric cancer (source: Euretos AI Platform)

In the area of cell and molecular dysfunctions, AEBP1 is involved in metaplasia and DNA damage, which is closely related to processes such as proliferation, migration, invasion, metastasis and epithelial-mesenchymal transition that are mentioned in the article.

Figure 5: Cell & Molecular Dysfunctions analysis of AEBP1 and it’s gene interactome revealing key associations with gastric cancer (source: Euretos AI Platform)

At the organ and tissue function level, finally, AEBP1 is involved in the formation of blood vessels (angiogenesis), a key aspect of tumor growth and suppressing the immune response, key to tumor survival.

Figure 6: Organ & Tissue Function analysis of AEBP1 and it’s gene interactome revealing key associations with gastric cancer (source: Euretos AI Platform)

In conclusion, although very limited direct literature exists of the involvement of AEBP1 in gastric cancer, the Gene-Disease Analysis workflow reveals many relevant associations with gastric cancer. Through its gene interactions AEBP1 is involved in various mechanisms that are key tumorigenesis, tumor growth, metastasis and survival.

The full analysis is available on request via the contact form on the Euretos website or at information@euretos.com

Read more news articles: Euretos News

About this series - The purpose of the Euretos Research Note series is to provide a data analytics perspective on recent life sciences publications. The series focuses on two types of questions: (1) Did the available data already point in the direction of a discovery? (2) What further research angles does the available data suggest?